邻居暴露基因和遗传风险之间的相互作用 在儿童精神病类经历中
Yinxian Chen1, Qingyue Yuan2, Lina Dimitrov1
1Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
邻居环境暴露,而不是遗传风险,与儿童持续的令人痛苦的精神类似经历 (PLE) 有关. 较高的邻居暴露组分数增加了PLE几率,特别是在具有较低遗传倾向的人群中.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 精神病学流行病学 精神病学流行病学
- 遗传学 是一个遗传学.
背景情况:
- 儿童持续的令人痛苦的精神病类经历 (PLE) 是一个越来越令人担忧的问题.
- 遗传因素和邻居环境暴露都与PLE的发展有关.
- 影响持续痛苦PLE的特定基因环境相互作用在很大程度上是未知的.
研究的目的:
- 调查遗传风险和邻居环境暴露对大量儿童队列中持续痛苦的PLE的独立和互动影响.
- 确定遗传倾向是否会改变邻居暴露和PLE之间的关联.
主要方法:
- 利用了6449名青少年大脑和认知发展研究参与者的数据.
- 使用多祖先精神分裂症多基因风险评分 (SCZ-PRS) 评估遗传风险.
- 使用多维社区暴露组 (NE) 评分量化社区层面的环境暴露.
主要成果:
- 精神分裂症多原风险评分 (SCZ-PRS) 与持续的痛苦PLE没有显著的关联 (OR = 1.04,P = 0.280).
- 较高的邻近暴露组 (NE) 评分与持续痛苦的PLE (OR = 1.15,P = 0.003) 的几率增加有显著关联.
- 观察到一个显著的相互作用,其中NE得分和PLE之间的关联通过增加SCZ-PRS (OR = 0.92,P = 0.039) 被减弱,表明在某些环境中更高遗传风险的保护作用.
结论:
- 邻居环境暴露似乎是儿童持续痛苦PLE的重要驱动因素.
- 通过SCZ-PRS测量的遗传风险在这个队列中没有直接预测PLE.
- 有害的邻居暴露在基因脆弱性较低的儿童中,对持续的痛苦PLE的风险更大.
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