下垂体-甲状腺激素和相关指数在乙甲状腺2型糖尿病:与甲状腺结节的关联
Baolan Ji1, Shuwei Shi1,2, Hongyan Zhao1,2
1Department of Endocrinology, Linyi People's Hospital, Linyi, Shandong, 276034, People's Republic of China.
概括
甲状腺结节 (TNs) 在2型糖尿病 (T2D) 中很常见. 在患有T2D的雌性甲状腺腺体中,自由三甲状腺素 (FT3) 和甲状腺刺激激素指数 (TSHI) 与TNs有关,突出了糖尿病和甲状腺健康的性别特异性差异.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
- 甲状腺学 甲状腺学
背景情况:
- 糖尿病是甲状腺结节 (TNs) 的已知危险因素.
- 影响糖尿病患者的TN的因素,特别是甲状腺功能良好的个体,需要进一步澄清.
- 以前的研究表明甲状腺激素 (TH) 功能和TNs之间存在联系,但这在2型糖尿病 (T2D) 患者中尚不清楚.
研究的目的:
- 在2型糖尿病 (T2D) 患者中研究甲状腺结节 (TNs) 的相关性.
- 在这个人群中探索甲状腺激素和TN之间的关系中的潜在性别差异.
主要方法:
- 一项涉及1965年2型甲状腺疾病的成年人进行的横截面研究.
- 收集临床和生化数据,包括甲状腺激素 (TH) 和相关共变量.
- 对TNs的超声波评估,使用单变量和多变量逻辑回归分析,按性别分层.
主要成果:
- 总体TNs的患病率为51.9%,女性患病率更高.
- 在女性中,自由三甲状腺素 (FT3) (OR: 1.381) 和甲状腺刺激激素指数 (TSHI) (OR: 0.740) 独立地与TNS相关.
- 没有发现甲状腺激素相关的指标与男性的TNs独立相关.
结论:
- 甲状腺激素和TNs之间的关联表明,甲状腺T2D患者的性别差异显著.
- 自由三甲状腺氨酸 (FT3) 和甲状腺刺激激素指数 (TSHI) 独立地与女性特异性TNs相关.
- 监测甲状腺荷尔蒙对于早期检测和治疗TNs至关重要,特别是在无甲状腺女性T2D患者中.
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