在晚期CKD中,囊素C与肌素eGFR对比:对STOP-ACEi试验的分析
Sebastian Spencer1,2,3, Robert Desborough2,3, Samir Mehta4
1University of Hull.
Clinical kidney journal
|March 4, 2025
概括
在晚期慢性病 (CKD) 中中止氨酸-血管酶系统抑制剂治疗并没有显著改变36个月内氨酸C估计的淋巴球过率 (eGFR). 赛斯塔丁C eGFR是晚期CKD中肌素eGFR的可靠替代品.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 生物标志物 生物标志物
背景情况:
- 对STOP-ACEi试验的二次分析.
- 专注于晚期慢性病 (CKD).
- 研究的氨酸-动脉素系统抑制剂 (RASi) 治疗对囊素C估计的淋巴球过率 (eGFR) 的影响.
研究的目的:
- 评估停止或继续RASi治疗对晚期CKD患者的cystatin C eGFR的影响.
- 在这个人群中,将囊素C eGFR与传统的基于肌素的 eGFR进行比较.
主要方法:
- 在多个时间点使用CKD-EPI 2012,EKFC和CKD-EPI合并2021方程计算了cystatin C的eGFR.
- 采用了完整的案例分析,混合效应线性回归,模式混合模型和联合模型.
- 被排除在外的样本在置换治疗开始后.
主要成果:
- 在12个月,24个月和36个月的STOP和CONTINUE臂之间,平均囊素C eGFR没有显著差异.
- 估计的最小平方平均差异范围从-1.46到-2.27 mL/min/1.73 m2.
- 灵敏度和联合模型支持了主要的发现.
结论:
- 停止RASi治疗与继续治疗晚期CKD相比,对cystatin C eGFR产生类似的影响.
- 囊素C eGFR是肌素eGFR的可靠替代品,特别是当肌素精度在晚期CKD中受到损害时.
相关概念视频
Factors Affecting Renal Clearance: Renal Impairment
47
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
47
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
447
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
447
Renal Clearance
669
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
669
Determination of Renal Drug Clearance: Graphical and Midpoint Methods
65
Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
65


