怀孕第二个三个月的功能指标和子宫前之间的关系:一个回顾性研究
Mingwei Li1, Wei Liu2, Xizhenzi Fan3
1Medical Affairs Department, the Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei Province, China.
PeerJ
|March 4, 2025
概括
血清尿酸和其与肌素的比率在第二个三个月升高表明孕前 (PE) 风险. 监测这些功能指标可以改善早检和孕妇PE的管理.
科学领域:
- 产科和妇科 产科和妇科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 孕前 (PE) 对母亲和新生儿的健康构成重大风险.
- 在怀孕期间早期识别PE风险因素对于及时干预至关重要.
- 第二个三个月的功能指标可以预测PE的发展.
研究的目的:
- 为了研究血清功能标志物和PE在怀孕第二个三个月之间的关联.
- 确定这些指标的最佳临界值.
- 确定PE的独立风险因素.
主要方法:
- 一个案例对照研究,比较137名孕妇与PE和137名控制在他们的第二个三个月.
- 血清尿酸,血清肌素和它们的比例的评估.
- 统计分析包括t测试,曼-惠特尼U测试,奇方测试,ROC曲线分析和后勤回归.
主要成果:
- 在PE组显著更高的血清尿酸和血清尿酸/肌素比率 (P < 0.001).
- 血清尿酸升高 (aOR=1.012) 和血清尿酸/肌素比率升高 (aOR=1.190) 被确定为PE的独立风险因素.
- 在PE组中,孕产妇和新生儿不良后果的发病率更高 (P < 0.001).
结论:
- 第二个三个月的血清尿酸和血清尿酸/肌素比率升高是PE的潜在早期标志物.
- 这些指标可能有助于识别患PE风险较高的孕妇.
- 针对性监测和管理高风险的个人在第二个三个月期间可以提高干预的有效性.
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