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Updated: May 24, 2025

Proteomic Analysis of Human Macrophage Polarization Under a Low Oxygen Environment
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急性缺氧调节巨细胞表型,伴随着转录组重编程和代谢重建模型

Binda Sun1,2,3, Yao Long1,2,3, Gang Xu1,2,3

  • 1Institute of Medicine and Equipment for High Altitude Region, College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China.

Frontiers in immunology
|March 4, 2025
PubMed
概括

急性缺氧抑制了巨细胞的增殖和细胞分裂,但重编程了它们的转录和新陈代谢. 巨细胞通过改变炎症反应和增强酸通路来适应低氧气,以求生存.

关键词:
急性低氧症是指急性低氧症.巨细胞是一个巨细胞.代谢性改造 代谢性改造酸酸盐路径的酸路径转录组重新编程转录组重新编程

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Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
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