分子遗传对注意力控制和其他执行过程的影响及其与AFFECT研究中的精神病理学的联系
Justin D Tubbs1,2,3,4, Travis T Mallard1,2,3,4, Maria Dalby5
1Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
medRxiv : the preprint server for health sciences
|March 4, 2025
概括
影响注意力控制的遗传因素与一般执行功能不同. 这些独特的遗传因素 (共同执行功能和注意力控制) 显示出与精神疾病 (包括ADHD) 有独特的联系.
科学领域:
- 神经科学是一个神经科学.
- 精神病学遗传学 精神病学遗传学
- 认知科学 认知科学
背景情况:
- 注意力控制是关键的执行功能,与各种精神和神经疾病有关.
- 注意控制与其他认知/行为特征之间的病因联系尚未完全理解.
研究的目的:
- 进行第一个分子遗传对注意力控制和执行功能的影响的多变量表征.
- 在大型队列中探索认知任务之间的遗传协差及其与临床和成像表型的关系.
主要方法:
- 在一个超过2万个人的队列中利用了基因组结构方程建模 (GSSEM).
- 基于任务的执行功能与其他表型之间的基因共变模拟.
主要成果:
- 确定了两个独立的潜在遗传因素:共同执行功能 (CEF) 和注意力控制 (AC).
- 无论是CEF还是AC因素,都显示出与认知和临床表型的遗传相关性,包括ADHD责任.
- 经过多次比较校正后,与成像衍生的表型的遗传相关性是适度且无意义的.
结论:
- 对注意力控制的遗传影响与对更广泛执行功能的遗传影响在很大程度上是分开的.
- 独特的CEF和AC遗传模式与认知和精神病的结果重叠.
- 强调了详细的认知表型对于理解精神病理病因学的重要性.
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