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脂质过氧化和结直肠癌风险:一个随时间变化的关系

Gong Yang, Ginger L Milne, Marina S Nogueira

medRxiv : the preprint server for health sciences

|March 4, 2025

概括

系统性氧化应激,通过尿液F2-异质来测量,显示了人类人群中与结直肠癌风险的反向和时间依赖的关联. 这些生物标志物的较高水平与降低的风险相关,特别是在癌症发展的后期阶段.

科学领域:

在瘤学瘤学.
生物化学生物化学
流行病学流行病学

背景情况:

氧化应激 (OxS) 与癌症的发展有关.
以前的研究表明,核酸氧化标志物与结直肠癌 (CRC) 风险之间存在逆相关性.
对其他OxS标志物的进一步研究,如脂质过氧化,是有必要的.

研究的目的:

调查系统性脂质过氧化与CRC风险之间的关联.
为了确定在实验模型中观察到的OxS和瘤发生之间的时间依赖关系是否存在于人类的系统水平.

主要方法:

嵌套病例控制设计利用了中国上海的两个潜在队列和一个独立的美国队列.
通过尿路F2-异质 (F2-IsoPs) 评估的系统性脂质过氧化,使用UPLC-MS/MS.
用于计算CRC风险的几率比率 (ORs) 的多变量条件逻辑回归.

主要成果:

尿中5-F2t-IsoP水平升高与上海和美国队列中CRC风险降低有关.
这种反向关联是时间依赖的,在癌症发展的后期阶段 (入学后5年内) 更明显.
对DNA,RNA和脂质OxS标记物的综合指数显示,与CRC风险的反向关联更强.

结论:

系统性氧化应激,特别是脂质过氧化,与人类的CRC风险相反且时间依赖.
这些发现支持OxS和瘤发生之间存在系统性,时间依赖的关系.
尿液中的F2-异素可以作为CRC风险评估的潜在生物标志物.

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