免疫印记和疫苗接种间隔根据XBB.1.5单价疫苗免疫性XBB.1.5单价疫苗免疫性
medRxiv : the preprint server for health sciences
|March 4, 2025
概括
随着SARS-CoV-2的发展,COVID-19疫苗更新至关重要. 免疫印记和暴露间隔显著影响了像XBB.1.5这样的更新疫苗如何提高对新变种的抗体反应.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19疫苗每年都会更新,以准流通中的SARS-CoV-2血统,例如JN.1.
- 来自祖先的尖蛋白暴露的免疫印记影响了对更新疫苗的反应.
- 了解免疫印记和暴露间隔对于优化COVID-19疫苗接种战略至关重要.
研究的目的:
- 评估先前接受或未接受双价疫苗的个体对XBB.1.5单价疫苗的抗体反应.
- 评估免疫印记和暴露间隔对针对SARS-CoV-2变种的疫苗免疫性的影响.
- 根据疫苗接种史,比较针对XBB.1.5,EG.5.1和JN.1变种的抗体增强.
主要方法:
- 对两组抗体反应 (中和抗体,IgA,IgG/A/M同型) 的比较分析:双价受体和双价非受体.
- 疫苗接种后对祖先和变种SARS-CoV-2菌株的评估抗体标位和宽度.
- 与疫苗接种史和暴露间隔相关的抗体反应.
主要成果:
- 与双价非接受者相比,与双价接受者相比,XBB.1.5,EG.5.1和JN.1变异的中和抗体的增强更大.
- 在非受体中,IgA和总IgG/A/M同型的增强被观察到,但不是IgG或IgM.
- 在这两组中都出现了祖先SARS-CoV-2标位的显著"反向增强",表明持续的免疫印记.
结论:
- 免疫印记继续影响对当代COVID-19疫苗的反应.
- 暴露间隔在抗体增强中发挥作用,尽管在本研究中,其贡献与双价疫苗接种史交织在一起.
- 这些发现强调了考虑免疫印记和暴露间隔对于变种适应的COVID-19疫苗策略的重要性.
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