维生素D缺乏在胎盘功能障碍中的作用:系统性审查
Eleni Gerovasili1, Antigoni Sarantaki1, Anastasia Bothou1
1Department of Midwifery, Faculty of Health and Caring Sciences, University of West Attica, Egaleo, Greece.
Metabolism open
|March 4, 2025
概括
母亲的维生素D缺乏会损害胎盘功能,增加妊娠并发症的风险. 补充活性维生素D (1α,25(OH) 2D3) 可以减轻这些不良影响,改善孕产妇和胎儿的健康.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 维生素D对胎盘发育和功能至关重要,影响血管生成,免疫调节和营养物质运输.
- 孕期维生素D缺乏与妊娠前兆,子宫内生长限制 (IUGR) 和早产等不良妊娠结果有关.
- 维生素D在胎盘功能障碍中的作用背后的机制需要进一步阐明.
研究的目的:
- 系统地审查研究维生素D与胎盘功能之间的关联的人类研究.
- 综合目前关于维生素D缺乏如何影响胎盘健康和怀孕结果的证据.
主要方法:
- 按照PRISMA指南进行了系统审查.
- 在PubMed,Scopus和Web of Science进行了搜索,寻找过去20年内发表的研究.
- 包括的研究是研究维生素D和胎盘功能的人类试验 (RCT,队列,病例控制),在质量评估后选择了10项研究.
主要成果:
- 母亲的维生素D缺乏会损害胎盘功能,损害血管完整性,降低营养物质输送者的调节,并增加炎症.
- 有证据表明,在维生素D缺乏的怀孕中,血管内皮生长因子 (VEGF) 减少,炎症性细胞因子增加.
- 补充活性维生素D (1α,25(OH) 2D3) 逆转了这些负面影响,改善了胎盘生长和减少炎症.
结论:
- 维生素D对于保持最佳的胎盘功能和确保怀孕的积极结果至关重要.
- 需要标准化维生素D补充方案,以及研究长期和人群特异性影响.
- 解决知识差距可以指导干预措施,以减少怀孕并发症和提高孕产妇和胎儿的健康.
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