气管置换:一个范围审查
Darin T Johnston1,2, David B Powers2, Matthew G Hartwig3
1Uniformed Services University, Craniomaxillofacial Trauma & Reconstruction, Oral & Maxillofacial Surgery, David Grant Medical Center, Travis AFB, California.
长段气管置换方法的结果各不相同. 合成材料的结果很差,而尸体气管异位移植的数量有限. 血管复合异体移植和异体移植需要免疫抑制.
科学领域:
- 胸部外科手术 胸部外科手术
- 再生医学是一种再生医学.
- 生物材料是一种生物材料.
背景情况:
- 气管替换对于广泛的气道缺陷至关重要.
- 历史和当前的技术在患者的结果上有很大差异.
- 了解这些差异对于临床决策至关重要.
研究的目的:
- 总结患者的特征和长段气管置换的结果.
- 为了比较空气管重建的历史和当前方法.
- 确定不同气管置换策略的局限性和益处.
主要方法:
- 系统审查英语语言研究.
- 纳入标准:有270度以上的宫气管置换的人类受试者.
- 排除标准:仅限于一次性解剖,收回的文章,非人体研究.
主要成果:
- 在32篇文章中报告了156例长段气管置换病例.
- 合成假肢 (如,马雷克斯) 的长期存活率很低.
- 尸体气管异位移植,大动脉异位移植,自由组织移植,异位移植和血管复合异位移植 (VCAs) 显示出具有特定限制的可变生存率.
结论:
- 合成气管假肢的长期结果是不充分的.
- 尸体气管异位移植仅限于良性病理,由于近周围缺陷替换.
- 异体移植和VCA缺乏粘膜清除,风险粘膜堵塞和感染;VCA和异体移植需要长期免疫抑制.
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