慢性阻塞性肺病患者视网膜神经纤维层厚度的变化:系统性审查和元分析
Yunpeng Xu1, Peidong Shi2, Xiaoying Liu2
1The First Clinical Medical College of Lanzhou University, Lanzhou, China.
The clinical respiratory journal
|March 4, 2025
概括
视网膜神经纤维层 (RNFL) 厚度在慢性阻塞性肺病 (COPD) 患者中显著降低. 这种稀薄,特别是在下部RNFL,与COPD严重程度相关,可能表明早期疾病变化.
科学领域:
- 眼科医生 眼科 眼科
- 肺部病理学 肺部病理学
- 医疗成像医学成像
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
- 眼部微血管变化在全身性疾病中越来越被认可.
研究的目的:
- 调查视网膜神经纤维层 (RNFL) 厚度与慢性肺炎的存在和进展之间的关联.
- 为了确定RNFL稀释是否是COPD的潜在生物标志物.
主要方法:
- 对已发表的研究进行了全面的元分析.
- 搜索包括主要的数据库 (PubMed,Embase等). 在2024年3月之前.
- 包括15项研究,共有1455名参与者 (801名COPD,654名对照).
主要成果:
- 与健康个体相比,COPD患者在所有测量象限中显著减少了RNFL厚度.
- 在严重的COPD病例中,减少更为明显.
- 在轻度/中度的COPD中,只有下级RNFL显示出显著的稀释.
结论:
- 平均和区域RNFL厚度在COPD患者中明显较低.
- RNFL稀释与COPD的严重程度有关.
- 较低的RNFL变化可以作为COPD发病和进展的早期指标.
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