低FODMAP饮食对肠道微生物群调节的影响:系统性审查和元分析
Panpan Chu1, Ying He1, Fenglan Hu1
1Department of Biological and Food Engineering, Lyuliang University, Lyuliang City, Shanxi Province, China.
Journal of food science
|March 4, 2025
概括
低FODMAP饮食对整体肠道微生物群的调节有积极的影响. 然而,这种效应在患有刺激性肠综合征 (IBS) 的个体中不那么显著. 需要进一步的研究来证实这些发现.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道微生物群在胃肠道健康中起着至关重要的作用.
- 越来越多地探索饮食干预措施来调节肠道微生物群.
- 低发酵性寡糖,分糖,单糖和多醇 (FODMAP) 饮食是一种流行的饮食方法,用于治疗胃肠道症状.
研究的目的:
- 系统地审查和元分析低FODMAP饮食对肠道微生物群调节的影响.
- 评估低FODMAP饮食对肠道菌群组成的影响.
- 为了研究一般人群和刺激性肠综合征 (IBS) 患者之间的潜在影响差异.
主要方法:
- 在多个数据库 (PubMed, Cochrane, Web of Science, Embase, CNKI, Wanfang) 中进行全面的文献搜索.
- 包括随机对照试验 (RCT),将低FODMAP饮食与正常饮食进行比较.
- 使用随机效应模型进行元分析,以计算标准化平均差异 (SMD) 和95%置信区间 (CI).
- 使用I2统计和出版偏差使用漏斗图表和埃格尔测试对异质性的评估.
主要成果:
- 分析了10个涉及590名参与者的RCT.
- 与正常饮食相比,低FODMAP饮食对肠道微生物群有显著的积极影响 (SMD = 0.33,p = 0.003).
- 发现了相当大的异质性 (I2 = 67.5%).
- 在IBS患者的亚组分析显示,饮食 (SMD = 0.08,p = 0.306) 与低异质性 (I2 = 17.0%) 之间没有显著差异.
- 没有发现显著的出版偏差 (Egger的测试,p = 0.328).
结论:
- 低FODMAP饮食可能会积极影响肠道微生物群的调节.
- 对肠道微生物群的有益影响在IBS患者中似乎不那么明显.
- 需要进一步进行高质量的研究来证实这些发现,并探索各种胃肠道疾病的长期影响.
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