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虚拟双胞胎方法使用基于生理学的药理动力学建模在接受apixaban或rivaroxaban治疗的住院患者中

Frédéric Gaspar1,2,3,4, Jean Terrier5,6,7, Celestin Jacot-Descombes2,7

  • 1Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

British journal of clinical pharmacology
|March 4, 2025
PubMed
概括

基于生理学上的药理动力学 (PBPK) 模型准确地预测了住院患者的阿皮克萨班和里瓦罗克萨班药物暴露. 这种方法有助于识别处于低剂量或过量剂量风险的个体,提高患者的安全.

关键词:
PBPKK PBPK 的意思是什么意思艾皮克萨班 (Apixaban) 是一种这是一种直接的口服抗凝剂.基于生理学的药理动力学.里瓦罗克萨班 (Rivaroxaban) 是一个

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