在老年男性肥胖和低雄性疾病的生活方式治疗期间,肌肉转录组形状的激素调节
Viola Viola1,2,3, Tagari Samanta4, Maria Liza Duremdes Nava1,2
1Center for Translational Research on Inflammatory Diseases, Michael E DeBakey VA Medical Center, Houston, Texas, USA.
Journal of cachexia, sarcopenia and muscle
|March 4, 2025
概括
替代疗法 (TRT) 与生活方式改变相结合,有助于肥胖和低的老年男性保持肌肉质量和骨密度. 这项研究揭示了TRT对抗减肥诱导的基因下调,支持肌肉和骨的健康.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 分子生物学分子生物学
背景情况:
- 在减肥期间,肥胖和阴性腺体缺陷症的老年男性会经历肌肉和骨损失.
- 当与生活方式治疗相结合时,替代疗法 (TRT) 可能会减轻这些损失.
研究的目的:
- 研究TRT在强化生活方式干预期间减轻肌肉和骨矿物质密度 (BMD) 损失的分子机制.
- 了解TRT如何影响与肌肉和骨代谢相关的基因表达在老年,肥胖的男性中.
主要方法:
- 随机对照试验 (LITROS) 涉及83名肥胖和阴阴腺症的老年男性 (≥65岁).
- 参与者接受了26周的生活方式治疗,再加上TRT或安慰剂.
- 用下一代测序和RT-PCR分析肌肉活检以评估基因表达变化.
主要成果:
- 与安慰剂相比,TRT保持了瘦身量和大腿肌肉体积,尽管体重减轻类似.
- 在TRT组中,部BMD保持不变,而在安慰剂组中则下降.
- 在安慰剂组中观察到的肌肉和骨 anabolic 基因的下调,TRT 抵消了,上调关键基因,如 MYOD1 和 WNT4.
结论:
- 除了生活方式治疗之外,TRT还有效地减轻了老年男性因减肥而导致的肌肉质量和BMD减少.
- 该机制涉及抵消对肌肉和骨类解体至关重要的基因的下调.
- TRT支持肌肉系统过程和骨矿化,为这一群体提供治疗策略.
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