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Updated: May 24, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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小分子抑制剂的进化Mycobacterium结核病 门宁生物合成

Pankaj Sharma1, Quan Jiang1, Shao-Gang Li1

  • 1Department of Pharmacology, Physiology, and Neuroscience, Rutgers University - New Jersey Medical School, Newark, New Jersey 07103, United States.

Journal of medicinal chemistry
|March 4, 2025
PubMed
概括

研究人员优化了JSF-2911,一个MenG酶抑制剂,创造了针对Mycobacterium结核病的新药. 像JSF-4898这样的新化合物显示出强度和疗效的提高,为结核病治疗提供了一个有前途的战略.

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