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Updated: May 24, 2025

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
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Published on: January 23, 2018

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类似PA1b的可以缓解由葡萄糖毒性引起的线粒体功能障碍,通过与β细胞中的VDAC1相互作用来缓解

Huizhong Huang1, Xinyu Zeng1, Liying Zhang1

  • 1Sino-German Biomedical Center, Hubei Provincial Key Laboratory of Industrial Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, 430068 Wuhan, Hubei, China. yaochenguang@hbut.edu.cn.

Food & function
|March 4, 2025
PubMed
概括

来自大豆的PA1b类可以通过与VDAC1,一种关键的线粒体蛋白相互作用来保护胰腺β细胞. 这种相互作用恢复了线粒体功能和胰岛素分泌,为2型糖尿病提供了新的治疗策略.

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