在小儿肠道衰竭患者中进行多组组学分析和亲肠营养断奶:一个纵向队列研究
Niklas Tappauf1,2, Yvonne Lamers1,2, Ho Pan Sham2,3
1Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada.
JPEN. Journal of parenteral and enteral nutrition
|March 4, 2025
概括
功能性微生物组特征和血液代谢物对预测肠道功能在肠道衰竭 (IF) 患者有希望. 这些发现可能有助于预测切断关节营养 (PN) 的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 肠道衰竭 (IF) 是一种严重的疾病,具有有限的生物标志物来预测患者的结果或从肠道营养 (PN) 断奶.
- 准确预测临床轨迹和PN断奶潜力对于管理IF患者至关重要.
研究的目的:
- 为了确定潜在的预测器的肠功能和PN断奶潜力在儿科患者与IF.
- 将肠道微生物组特征和血液分析物与PN依赖性联系起来.
主要方法:
- 对18名儿科IF患者进行长度多组组队列研究,治疗PN长达1.5年.
- 用于肠道微生物组分析 (细菌和真菌) 的metagenomic猎枪和ITS2rRNA测序.
- 针对257种血液分析物的向代谢量;用于关联分析的线性混合模型.
主要成果:
- 细菌和真菌的分类组合显示出高度的变异性,没有与PN依赖的联系.
- 在63种细菌MetaCyc通路和PN依赖之间发现了显著的关联.
- 32个血液分析结果与PN依赖有显著的关联.
结论:
- 功能性微生物组特征和血液代谢概况显示出预测肠道功能的前景.
- 尿素循环代谢产物,肌素,氨酸和氨酸代谢产物是潜在的生物标志物.
- 研究结果表明,促进肠道适应具有治疗意义,需要进行更大规模的验证研究.
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