中年和老年人视网膜加快衰老和多病症
Ruiye Chen1,2,3, Xiaomin Zeng3, Wenyi Hu1,2,3
1Centre for Eye Research Australia; Ophthalmology, University of Melbourne, Melbourne, Australia.
GeroScience
|March 4, 2025
概括
视网膜年龄差距较大,表明衰老速度较快,与患多种健康状况 (多重疾病) 的风险更高有关. 这一发现可能有助于识别需要早期干预以改善健康管理的个人.
科学领域:
- 眼科和老年病学 眼科和老年病学
- 计算医学是一种计算医学.
- 公共卫生 公共卫生
背景情况:
- 视网膜年龄差距是从视网膜图像中获得的生物衰老的衡量标准,是整体健康状况的潜在指标.
- 多病性,即多种慢性疾病的同时发生,构成了重大的公共卫生挑战.
- 了解多病症预测因素对于早期检测和干预至关重要.
研究的目的:
- 调查视网膜年龄差距与基线多病性存在之间的关联.
- 检查视网膜年龄差距与随时间推移新发多发症的发生率之间的关系.
主要方法:
- 使用深度学习模型计算了45436名参与者的视网膜年龄差距.
- 多发病症被定义为在基线时具有零,一个或至少两个与年龄相关的疾病.
- 事件多病症被定义为在随访期间发展两个或两个以上的与年龄有关的疾病.
- 线性和考克斯比例危险回归模型被用于分析数据.
主要成果:
- 现有多种疾病或一种疾病的参与者在基线时显示出显著更大的视网膜年龄差距.
- 视网膜年龄差距每增加5年,就会增加8%的发生多发病的风险.
- 随访期间的中位数为11.38年,其中17.29%的参与者发展了事件多病症.
结论:
- 增加的视网膜年龄差距是一个独立的预测器,可以预测患多病症的风险更高.
- 视网膜衰老的偏差可以识别患多病风险较高的个体.
- 通过视网膜年龄差距评估早期识别可以促进个性化干预和自我管理.
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