成人一般ICU患者的一套核心结果
Maj-Brit Nørregaard Kjær1,2, Camilla Rahbek Lysholm Bruun1, Anders Granholm1,2
1Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Critical care medicine
|March 4, 2025
概括
研究人员为成人重症监护室 (ICU) 患者制定了一套核心结果. 这一标准化套件确保在临床试验中进行一致的测量,以获得更好的患者结果.
科学领域:
- 关键护理医学 关键护理医学
- 临床试验方法论 临床试验方法论
- 患者为中心的研究成果研究成果
背景情况:
- 协调的结果对于临床实践至关重要,尤其是在大型实用性试验中.
- 对于特定的ICU子组 (例如,呼吸衰竭,妄想,COVID-19),现有的核心结果集存在,但对于一般的成人ICU人群而言没有.
- 对于成人一般ICU患者,需要一个普遍适用的核心结果集.
研究的目的:
- 为成人一般重症监护病房 (ICU) 患者制定和国际验证一个核心结果集.
- 建立一套标准化结果,用于临床研究和涉及该患者群体的试验.
主要方法:
- 采用了经过修改的德尔菲共识过程,包括文献评论,调查和半结构面试.
- 该研究涉及五个丹麦研究小组,并在14个国家获得国际验证.
- 参与者包括成年ICU幸存者,家庭成员,临床医生和研究人员.
主要成果:
- 确定了一组最初的329个结果,其中50个包括在Delphi调查中的264名参与者中.
- 与82名参与者的半结构面试没有产生额外的结果.
- 最后,国际验证的核心结果集包括六个结果:生存,没有生命支持,没有妄想,出院,与健康有关的生活质量和认知功能.
结论:
- 一套包含六个核心结果的核心结果已经成功开发和验证.
- 这一核心结果集旨在用于研究,特别是在涉及成人一般ICU患者的临床试验中.
- 已建立的集合促进了在重症监护研究中的标准化结果测量.
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