高剂量流感疫苗对老年人天生的免疫力产生增强作用
Olivia Bonduelle1, Tristan Delory2, Isabelle Franco-Moscardini1
1Sorbonne Université, Institut National de Santé et de Recherche Médicale, Inserm U1135, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
JCI insight
|March 4, 2025
概括
高剂量四价流感疫苗 (QIV-HD) 在老年人中,比标准剂量 (QIV-SD) 更多地增强了抗体反应. 这与年轻的天生的免疫基因表达模式有关,增强了疫苗的疗效.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 老年学是一门学科.
背景情况:
- 高剂量四价流感疫苗 (QIV-HD) 在老年人中表现出比标准剂量 (QIV-SD) 更高的疗效.
- 这种增强的疗效背后的确切免疫机制仍需要阐明.
研究的目的:
- 在65岁以上的个体中,比较QIV-HD与QIV-SD诱导的早期先天性免疫反应.
- 为了研究先天细胞和基因表达特征和疫苗接种后的幽默反应之间的关系.
主要方法:
- 第四期随机对照试验涉及59名年龄大于65岁的参与者.
- 在接种疫苗后的0日和1日评估系统性先天细胞和基因表达.
- 在0日和21日测量血凝素抑制抗体 (HIA) 标位.
主要成果:
- 与QIV-SD相比,QIV-HD诱导的HIA标位和血清转化率显著更高.
- 接种QIV-HD的人在接种疫苗后的第一天表现出降低的先天细胞 (DCs,NK细胞),与较高的D21 HIA标位相关.
- 血液转录组显示,QIV-HD组的基因表达幅度更大,涉及先天免疫,IFN和抗原呈现途径,与幽默反应相关.
结论:
- 在老年人中,QIV-HD引发了比QIV-SD更强大的幽默免疫反应,由更高的HIA标位证明.
- 随着QIV-HD的增强反应与与年轻成年人相似的先天基因表达特征相关,这表明"青春的提升".
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