细颗粒物暴露和发生的亚托皮性皮炎:一个出生队列研究
Lih-Hwa Lin1, Chung-Chin Lee2, Meng-Min Hwang3
1Division of Chinese Medicine, An Nan Hospital, China Medical University, Tainan, Taiwan.
The British journal of dermatology
|March 4, 2025
概括
在怀孕和婴儿期暴露于细颗粒物 (PM2.5) 与患上亚托皮炎 (AD) 的风险更高有关. 敏感时期包括妊娠晚期和婴儿早期.
科学领域:
- 环境健康 环境健康
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
背景情况:
- 细颗粒物 (PM2.5) 暴露和从受孕到产后一年的亚托皮炎 (AD) 发展之间的联系需要进一步澄清.
- 了解关键曝光窗口对于预防AD至关重要.
研究的目的:
- 检查PM2.5暴露在怀孕和婴儿期对AD后续发展的影响.
- 为了确定脆弱的发育期和潜在的生物途径,涉及到PM2.5诱导的AD.
主要方法:
- 一项大型分娩队列研究包括了2004年至2013年间出生的564,869名预产婴儿,并一直跟踪到5岁.
- 基于卫星的建模估计了个人PM2.5暴露.
- 考克斯的比例危险和分布式滞后非线性模型分析了AD关联和剂量反应关系.
主要成果:
- 在被诊断患有AD的76,944名婴儿中,从怀孕34周到出生和从分娩后33周增加的累积PM2.5暴露与更高的AD发病率有显著的关联.
- 观察到剂量-反应关系,PM2.5暴露超过65μg m-3急剧增加AD风险.
结论:
- 产前和产后早期暴露于PM2.5与晚期发展的亚托皮炎有关.
- 怀孕晚期和婴儿早期似乎是PM2.5暴露导致AD的敏感时期.
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