糖尿病和高血葡萄糖在心脏膜化和疾病:哥本哈根一般人口研究
Morten Kaltoft1,2, Shoaib Afzal1,2,3, Børge G Nordestgaard1,2,3
1Department of Clinical Biochemistry, Copenhagen University Hospital - Herlev Gentofte, Denmark.
European journal of preventive cardiology
|March 4, 2025
概括
糖尿病和高血糖增加了主动脉和心心膜化和主动脉狭窄的风险. 这些风险部分是由甘油三,高血压和体重指数解释的.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 大动脉狭窄 (AVS) 需要更换门,强调需要可修改的风险因素识别.
- 糖尿病和高血糖是导致心血管疾病的潜在因素,包括膜病理.
研究的目的:
- 为了研究糖尿病,血葡萄糖升高和大动脉和心心膜的化之间的关联.
- 确定这些关联是否由血甘油三,高血压或体重指数 (BMI) 介导.
主要方法:
- 哥本哈根总人口研究包括110291名参与者进行健康登记册评估.
- 对12006名患者进行心脏CT扫描,以评估大动脉和心心膜化.
主要成果:
- 糖尿病与大动脉 (OR 1.67) 和中枢结石化 (OR 1.89) 和AVS (HR 1.71) 的几率增加有关.
- 血葡萄糖升高 (≥6.6 mmol/L) 与大动脉 (OR 1.27) 和中枢结石化 (OR 1.44) 以及AVS (HR 1.33) 有关.
- 高血压 (19%),BMI (27%) 和甘油三 (4.8%) 部分解释了糖尿病和AVS之间的联系.
结论:
- 糖尿病和血葡萄糖升高是大动脉和心心膜化和AVS的重要危险因素.
- 高血压,BMI和血甘油三部分介导糖尿病和大动脉狭窄风险之间的关系.
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