从焦虑症和抑郁症到心血管疾病的共同和独特途径:英国生物银行前性队列研究
Shinya Nakada1, Carlos Celis-Morales1,2,3,4, Jill P Pell1
1School of Health and Wellbeing, University of Glasgow, Glasgow, G12 8TB, UK.
European journal of preventive cardiology
|March 4, 2025
概括
焦虑症和抑郁症显著增加心血管疾病 (CVD) 的风险. 吸烟等生活方式因素和腰比等身体因素调解了这种风险,但两种情况之间的代谢途径不同.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 焦虑症和抑郁症是已知的心血管疾病 (CVD) 的风险因素.
- 将这些精神健康状况与心血管疾病联系在一起的具体机制需要进行系统的调查,特别是对比它们的差异.
研究的目的:
- 调查生活方式,身体和代谢因素在多大程度上调解焦虑症和抑郁症与发生心血管疾病之间的关联.
- 区分焦虑障碍和抑郁症与心血管疾病风险有关的调解途径.
主要方法:
- 一项使用英国生物库数据的前性队列研究.
- 通过链接医院和死亡记录,确定焦虑症,抑郁症和心血管疾病事件.
- 使用考克斯比例危险和日志线性模型检查生活方式,身体和代谢调解者的因果调解分析.
主要成果:
- 焦虑障碍 (HR 1.62) 和抑郁症 (HR 2.15) 都与心血管疾病风险增加有显著关联.
- 目前的吸烟和更高的腰比是这两种情况的关键生活方式/身体调解因素.
- 缩血压调解了焦虑障碍 (10.4%) 的心血管疾病风险,而CRP则调解了抑郁症 (10.8%).
结论:
- 生活方式和身体因素似乎是焦虑障碍和抑郁症中心血管疾病风险的常见调解途径.
- 焦虑症和抑郁症之间导致心血管疾病的共享代谢途径不太可能.
- 针对特定的生活方式和身体风险因素可以帮助减轻患有焦虑症或抑郁症的个体心血管疾病风险的增加.
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