细分重叠是常见的eosinophilic胃肠道疾病和影响临床表现和治疗的影响
Corey J Ketchem1, Elizabeth T Jensen2,3, Xiangfeng Dai3
1Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.
概括
异性胃肠道疾病 (EGIDs) 经常涉及多个胃肠道区域,特别是在患有食道疾病 (EGID-WE) 的患者中. 这种重叠与疾病负担增加以及特定的人口和治疗模式有关.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 生性胃肠道疾病 (EGIDs) 涵盖了一系列由生性肠道透为特征的疾病.
- 在EGID中重叠的肠道干部参与的程度和临床意义,超出性食道炎 (EoE),仍然不完全理解.
- 根据受影响的胃肠道区域了解表现差异对于优化患者管理至关重要.
研究的目的:
- 调查EGIDs中重叠的肠道干部参与的流行率和模式.
- 为了确定是否临床表现和治疗策略不同,基于GI参与程度.
- 分析与EGID参与相关的患者人口统计和结果.
主要方法:
- 来自EGID合作伙伴队列的数据分析,这是一个以患者为中心的在线研究网络.
- 仅EoE,非EoE EGID 没有食道干涉 (EGID-NE) 和 EGID 与食道干涉 (EGID-WE) 之间的患者特征和结果的比较.
- 利用在入学时完成的调查来收集人口统计,临床和治疗信息.
主要成果:
- 在非EoE EGID 中,重叠的肠道干扰是常见的,其中一半以上的病例表现出食道干扰 (EGID-WE).
- 与其他组相比,EGID-WE患者的EGID家族病史和焦虑得分较高的患病率更高.
- 在EGID-WE和EGID-NE患者中,使用元素配方,全身类固醇和生物药物等特定治疗方法更频繁.
结论:
- 多段性肠道干扰是非EoE EGIDs的常见特征,强调了这些疾病的全身性质.
- 患有EGID-WE的患者往往会经历更大的疾病负担,由更高的焦虑水平和特定的治疗需求表明.
- 这些发现强调了在EGID诊断和管理策略中考虑胃肠道重叠的重要性.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
376
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
376
01:21Barrett Esophagus-II: Clinical Manifestations and Management
93
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
93
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
44
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
44
01:30Inflammatory Bowel Disease II: Crohn's Disease
157
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
157
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
112
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
112
01:30Other Disorders of Digestive System
643
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
643