在一个多样化的队列中,从轻度认知障碍到双向过渡的预测者
Mitzi M Gonzales1,2, Roman Fernandez3, Sarah Kremen1
1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
概括
轻度认知障碍 (MCI) 的发展轨迹各不相同. 拉丁裔个体的痴呆症转化率低于非西班牙裔白人成年人,强调了对认知衰退预测的多样化研究需求.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 轻度认知障碍 (MCI) 轨迹是异质的,受到社会,医学和评估因素的影响.
- 种族和种族差异可能会影响MCI对痴呆症的预后意义.
- 了解MCI过渡对于不同的老龄化人口至关重要.
研究的目的:
- 评估非西班牙裔白人 (NHW) 和拉丁裔老年人的MCI过渡频率和相关变量.
- 为了比较痴呆症转化与认知无障碍 (CU) 逆转率后MCI诊断.
- 确定影响不同种族群体认知轨迹的因素.
主要方法:
- 利用多状态马尔科夫模型,分析了10年来认知不受损 (CU),MCI和痴呆状态之间的过渡.
- 包括413名参与者 (52%拉丁裔,平均年龄72岁).
- 使用危险比率 (HR) 和95%置信区间 (CI) 评估变量,包括GFAP和NfL等生物标志物.
主要成果:
- 在MCI诊断后,痴呆症转化和CU逆转同样可能.
- 高龄,NHW族裔,APOE ε4,糖尿病,较低的BMI和神经精神症状增加了痴呆症的风险.
- 较高的基线血清质纤维酸蛋白 (GFAP) 和神经丝光 (NfL) 与痴呆风险增加有关.
- 与NHW成年人相比,拉丁裔成年人表现出较低的痴呆症转化率.
结论:
- 患有MCI的轨迹是高度可变的,并观察到显著的种族差异.
- 基于血液的生物标志物 (GFAP,NfL) 在预测痴呆风险方面表现有前途.
- 多样化的研究代表性对于理解影响认知衰退和弹性因素至关重要.
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