患有多囊性卵巢综合征的姐妹的男性的不良心脏代谢结果
Aleksandra Kanina1, Elisabet Stener-Victorin2, Agnieszka Butwicka1,3,4,5
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
The Journal of clinical endocrinology and metabolism
|March 4, 2025
概括
患有多囊卵巢综合征 (PCOS) 姐妹的男性面临更高的肥胖,2型糖尿病和高血压风险. 这些发现强调了PCOS的家族影响,并建议对有风险的男性进行早期查.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病.
- 以前的研究表明,PCOS妇女的兄弟在心脏代谢功能障碍的潜在家族联系.
研究的目的:
- 调查患有PCOS的妹妹与男性不良心脏代谢结果之间的关联.
- 评估男性患有PCOS诊断的姐妹的肥胖,2型糖尿病和高血压的风险.
主要方法:
- 瑞典的一项基于人口的大型队列研究 (n=1,098,203) 追踪了从5岁到2018岁的男性.
- 考克斯回归模型被用来估计心脏代谢诊断的危险比率.
- 后勤回归分析了18-20岁评估的子队列中的关联.
主要成果:
- 患有PCOS姐妹的男性显著增加肥胖 (aHR:2.02),2型糖尿病 (aHR:1.62) 和高血压 (aHR:1.24) 的风险.
- 在成年早期 (18-20岁),一个患有PCOS的妹妹与超重 (aOR: 1.33) 和肥胖 (aOR: 1.78) 相关,但没有血压升高.
结论:
- 患有PCOS的妹妹与男性的不良心脏代谢结果有关,在成年早期出现.
- 这些发现强调了PCOS相关风险的家族聚类,并将患有PCOS的姐妹的男性确定为针对性查和预防策略的群体.
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