猪:猪功能基因组学研究的综合和全面的多omics数据库.
Guohao Han1,2,3, Peng Yang1,2,3,4,5, Yongjin Zhang2,3
1Kunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute, Chinese Academy of Agricultural Sciences, Foshan 528225, China.
Genomics, proteomics & bioinformatics
|March 4, 2025
概括
PIGOME是一个新的数据库,为功能基因组学提供各种各样的猪多omics数据. 该资源通过提供综合基因注释和可视化工具来帮助养猪和人类生物医学研究.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 动物科学动物科学
背景情况:
- 猪是重要的蛋白质来源,也是人类发展和疾病研究的关键模型.
- 在猪中进行广泛的高通量测序已经产生了大量数据,但专用的多omics数据库仍然有限.
- 猪的功能基因组学研究需要集成的,可访问的基因组学数据集.
研究的目的:
- 推出PIGOME,这是一个全面和用户友好的猪多omics数据数据库.
- 巩固多样化的OMIC数据集和相关元数据,以加强猪功能基因组学研究.
- 为探索猪的基因表达,表观遗传模式和特征关联提供工具.
主要方法:
- 汇编了七种类型的猪奥米克数据集:WGS,RNA-seq,miRNA-seq,ChIP-seq,ATAC-seq,BS-seq和MeRIP-seq.
- 整合了来自392个项目的6901个样本的数据,其中包括精选的元数据,基因注释和QTL信息.
- 开发了用户友好的"探索"和"浏览"功能以及对基因组变异,基因表达和表观遗传信号的可视化工具.
主要成果:
- PIGOME 收藏了大量的猪多omics 数据和丰富的元数据.
- 该数据库提供了综合基因注释和定量特征位置 (QTL) 信息.
- 可视化工具可以有效地探索时空基因表达,表观遗传模式和调控机制.
结论:
- PIGOME作为一个有价值的资源,用于推进猪功能基因组学和育种策略.
- 该数据库促进了对猪发育,疾病和经济特征的研究.
- PIGOME通过利用猪作为模型生物体来支持比较基因组学和人类生物医学研究.
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