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探索难以管理的轴性脊椎关节炎:来自荷兰临床实践注册表的结果
Marius L Smits1,2, Casper Webers1,2, Harald E Vonkeman3,4
1Department of Rheumatology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Rheumatology (Oxford, England)
|March 4, 2025
概括
大约10%的轴性脊柱关节炎患者患有难以管理的疾病 (D2M axSpA). 患者报告的结果对D2M axSpA的分类有显著的贡献,目前的吸烟和牛皮病史是相关因素.
科学领域:
- 类风湿病学 类风湿病学
- 临床实践 临床实践
- 疾病管理 疾病管理
背景情况:
- 轴性脊柱关节炎 (axSpA) 在临床管理中提出了挑战.
- 定义难以管理的 axSpA (D2M axSpA) 对有针对性的干预至关重要.
研究的目的:
- 为了确定D2M axSpA的患病率,使用国际脊柱状关节炎评估协会 (ASAS) 的定义.
- 确定ASAS定义中的哪些组件对于D2M axSpA.分类最为关键.
- 为了描述D2M axSpA.患者的特征.
主要方法:
- 一项采用SPA-Net注册表数据的横截面研究.
- 应用了ASAS对D2M axSpA的定义,考虑到治疗失败,疾病控制不足 (高疾病活性,活跃疾病症状或生活质量降低) 和有问题的管理.
- 后勤回归分析确定了相关的患者特征.
主要成果:
- 总体而言,9.7%的患者符合D2M axSpA标准,变化范围为3.6%至8.7%.
- 疾病控制不足是最常见的标准 (79.7%),其次是有问题的管理 (51.4-60.2%).
- 当前吸烟 (OR=3.1) 和前科牛皮 (OR=2.8) 与D2M axSpA有显著的相关性.
结论:
- 大约十分之一的axSpA患者经历了难以管理的疾病.
- 患者报告的结果在D2M axSpA.分类中起着至关重要的作用.
- 目前的吸烟和牛皮病史是D2M axSpA的关键相关因素.
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