精神分裂症中的外周微血管和脑白质功能障碍:身体-大脑内皮细胞病理生理学的影响
Eric L Goldwaser1, Alexa Yuen2, Wyatt Marshall2
1Weill Cornell Medicine, Department of Psychiatry, New York, NY 10065, United States.
Schizophrenia bulletin
|March 4, 2025
概括
精神分裂症谱系障碍与较差的外周血管健康和大脑中白质完整性的降低有关. 这些发现表明精神分裂症中存在身体与大脑的联系,需要采用整体方法来了解其原因.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症谱系障碍 (SSD) 是一种慢性神经精神疾病,与大脑异常和心血管风险增加有关.
- 导致SSD的遗传和环境因素可能会影响系统生理学,包括周围血管健康.
- 以前的研究表明,SSD和脑血管共同疾病之间存在联系,但与外周血管内皮质完整性和大脑白质微观结构的直接关系不太清楚.
研究的目的:
- 在SSD患者中研究外周血管内皮功能与白质 (WM) 微观结构之间的关联.
- 测试SSD风险因素影响外周血管完整性和大脑结构的假设.
主要方法:
- 通过使用手臂动脉封闭后反应性高血压 (PORH) 来评估外周微血管内皮功能.
- 白物质微观结构使用多扩散张力成像进行了评估.
- 该研究包括46名SSD患者和48名健康对照 (HC).
主要成果:
- 与HC相比,SSD的参与者表现出明显较低的PORH反应.
- 患有SSD的个体也表现出全脑小分异性变异 (FA) 的减少,这表明白质完整性较低.
- 在全样本中,特别是SSD组中,在PORH和全脑FA之间发现了显著的正相关性,这表明血管健康和大脑微观结构之间存在联系.
结论:
- 这项研究提供了第一个证据,表明SSD患者血管内皮完整性明显降低.
- 这些发现表明,SSD中受损的外周血管内皮和白质微观结构异常之间存在关联.
- 这些结果强调了整体,身体-大脑方法对于理解精神分裂症谱系障碍的病理生理学的重要性.
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