甘氨酸补充剂通过调节肠道微生物群,SCFA和肠道屏障功能,通过Wnt10b/NF-κB轴改善肉的骨质质量
Zeshan Zulfiqar1, Muhammad Arslan Asif1, Mengqi Liu1
1Department of Animal Nutrition and Feed Science, College of Animal Science, Henan Agricultural University, Zhengzhou, PR China.
Poultry science
|March 4, 2025
概括
有机 (Zn-Glycine) 补充剂显著改善了的骨质和肠道健康. -甘氨酸增强了骨矿物质密度,降低了肠道透性,并调节了肠道微生物群,突出显示了其对骨质恒温的好处.
科学领域:
- 动物营养 动物营养
- 骨生物学 骨生物学 骨生物学
- 肠道微生物组研究研究
背景情况:
- 骨疾病与肠道微生物群的改变和骨折风险增加有关.
- (Zn) 对于骨质平衡和腿部健康至关重要.
- 饮食中的来源会影响骨质和肠道健康.
研究的目的:
- 评估无机 (ZnSO4) 与有机 (Zn-Glycine) 对骨质量的影响.
- 调查Zn-Glycine对肠道微生物群,肠道屏障功能和骨周转的影响.
- 通过肠-骨轴探索Zn-Glycine对骨健康影响的潜在机制.
主要方法:
- 在60天的时间里,给300只子食补充了80毫克/公斤ZnSO4或80毫克/公斤Zn-Glycine.
- 评估骨矿物质密度 (BMD),灰百分比,骨长度和微型计算机断层扫描 (微型CT).
- 分析肠道微生物群组成,短链脂肪酸 (SCFA) 生产,肠道透性标记物,炎症性细胞因子,骨周转标记物,抗氧化能力和基因表达 (Wnt-10b,NF-κB).
主要成果:
- 与ZnSO4相比,Zn-Glycine显著增加了骨 BMD,灰百分比和骨长度.
- Zn-Glycine改善了肠道形态,调高了紧结蛋白,并增加了有益的细菌 (乳酸菌,双菌).
- Zn-Glycine增强了骨形成标记物 (ALP,Runx2,OPG,OCN,SMAD),减少了骨再吸收标记物 (TRAP,NFATC1,TRAF-6),增强了抗氧化能力,减少了细胞死亡标记物.
结论:
- 食Zn-Glycine有效地改善了肉的骨质和肠道健康.
- Zn-Glycine调节肠道微生物群,增强肠道屏障功能,并促进有利的骨循环平衡.
- 肠-骨轴起着至关重要的作用,Zn-Glycine影响关键信号通路,如Wnt-10b和NF-κB,以改善骨健康.
相关概念视频
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:31Essential Minerals for Bone Health
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:28Peptidoglycan Synthesis
Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
01:18Functions of the Gut Microbiota
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...