改变的大脑结构和功能与儿童和青少年患有跨诊断精神疾病的非自杀性自我伤害相关
Xuan Liu1, Yixin Zhang1, Jiahui Chen1
1School of Psychology, Shandong Normal University, Jinan, 250358, China.
Journal of psychiatric research
|March 4, 2025
概括
年轻人非自杀性自我伤害 (NSSI) 与膜体积和连接性降低有关. 这些大脑变化可能解释了内部化和外部化症状如何在疾病中增加NSSI严重程度.
科学领域:
- 神经科学是一个神经科学.
- 儿童和青少年精神病学 儿童和青少年精神病学
- 心理健康研究 心理健康研究
背景情况:
- 非自杀性自我伤害 (NSSI) 在患有各种精神疾病的年轻人中很常见.
- 以前的研究将NSSI与特定疾病中的大脑变化联系起来,但共同的机制仍然不清楚.
研究的目的:
- 在儿童和青少年的跨诊断队列中调查与NSSI共享的大脑结构和功能关联.
- 探索这些大脑变化是否调节或调节精神病症状和NSSI之间的关系.
主要方法:
- 利用线性回归模型对386名儿童和青少年 (ADHD,自闭症,泛性焦虑障碍) 的数据进行了健康大脑网络研究.
- 研究了NSSI严重程度与大脑体积 (N=386) 和功能连接 (N=277) 之间的关联.
- 评估了大脑变化在内化/外化症状与NSSI之间的联系中的调节/调解作用.
主要成果:
- 增加的NSSI严重程度与双边膜体积的减少相关.
- 观察到左门和双边关节之间,以及右门和左关节之间功能连接性减少.
- 较低的布坦体积或较弱的功能连接性缓和了内化/外化症状和NSSI严重性之间的关联.
结论:
- 年轻人的跨诊断NSSI与门的结构和功能变化有关.
- 布塔门可以作为NSSI的神经标记物,跨越精神疾病.
- 膜变化可能是儿童精神健康中NSSI的神经调制治疗的目标.
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