一个开源的,基于生理学的,对 brojler 和产母的 tylosin 的相互作用性药理动力学模型
Zhicheng Zhang1,2, Melissa A Mercer3, Lisa A Tell3
1Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32611, United States.
概括
一个新的基于生理学的药理动力学 (PBPK) 模型准确地预测了中的泰洛辛水平,确保了食品安全. 该工具有助于估计泰洛辛的禁用间隔,该抗生素对家禽健康至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 兽医医学 兽医医学 兽医医学
- 食品安全 食品安全
背景情况:
- 泰洛是一种宏类抗生素,在家禽中广泛用于治疗呼吸系统疾病.
- 标签外使用需要强有力的食品安全评估和准确的禁用期 (WDI) 估计.
研究的目的:
- 开发和验证一种基于生理学的药理动力学 (PBPK) 模型,用于肉和产母的泰洛辛.
- 为PBPK模型创建一个用户友好的界面,以促进食品安全评估.
- 根据已确定的监管容忍水平,估计产母的泰洛辛WDI.
主要方法:
- 开发一个包含各种组织 (血,作物,胃肠,肠道,肌肉,肝脏,脏,脂肪,生殖器官) 和生理参数的PBPK模型.
- 模型验证使用确定系数 (0.87对于 brojlers,0.78对于层) 来预测血,组织和卵中的 tylosin 度.
- 将模型转换为基于Web的可访问性应用程序.
主要成果:
- 该PBPK模型在不同组织和物种中预测泰洛辛的药理动力学方面表现出很高的准确性.
- 产母的估计WDI被确定为卵2.0天,脏3.0天,肝脏4.0天,肌肉2.0天,脂肪2.0天.
- 成功开发了一个用户友好的Web界面,增强了该模型的实际应用.
结论:
- 开发的PBPK模型是通过准确评估泰洛残留物来确保家禽生产中的食品安全的宝贵工具.
- 该模型有助于可靠地估计戒断时间,支持在中非标签使用泰洛辛.
- 这项研究为将类似的建模方法应用于其他兽医药物和家禽物种提供了基础.
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