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在未选定人群中的PCOS表型研究:定义hirsutism的基于人口的规范性切断的种族变化

Asmamaw Demis Bizuneh¹, Anju E Joham^1,2, Chau Thien Tay^1,2

¹Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria 3168, Australia.

European journal of endocrinology

|March 4, 2025

概括

在多囊卵巢综合征 (PCOS) 中的hirsutism诊断因种族而异. 这项研究为修改后的费里曼-加尔维 (mFG) 评分确定了特定种族的规范性截止值,有助于个性化PCOS诊断.

科学领域:

内分泌学在内分泌学.
生殖健康生殖健康
临床诊断临床诊断临床诊断

背景情况:

宫性是多囊性卵巢综合征 (PCOS) 的一个关键诊断特征.
目前的 hirsutism 定义经常使用任意的切断,缺乏基于人口的规范性数据.
希尔苏特症患病率和严重程度的种族差异是公认的,但在诊断标准中并不一致应用.

研究的目的:

通过使用修改后的费里曼-加尔维 (mFG) 尺度,为赫尔苏特主义建立特定种族的规范性截止值.
为了在全球不同的人口中比较hirsutism切断线.
为PCOS的诊断标准和个性化患者护理提供信息.

主要方法:

从未选择人群中的PCOS表型 (P-PUP) 研究中分析个人参与者数据 (IPD).
利用从mFG尺度直接评估的 hirsutism分数上的k-means集群分析.
包括来自8个国家的12项研究中的9829名参与者,代表不同的种族.

主要成果:

对于mFG得分的规范性截止值在各族群之间有很大的差异,从4到8不等.
白人伊朗人有最高的切割率 (8),其次是白人意大利人和黑人非洲人 (7).
一些民族,包括汉族,俄罗斯人,土耳其人和黑人美国人,共享了5或4的切割线.

结论:

这些发现支持2023年国际PCOS指南的一般mFG评分范围 (4-6),但强调需要考虑种族因素.
在mFG切断值的显著种族差异需要个性化的方法在hirsutism诊断.
临床医生应考虑患者的种族,以获得最佳的诊断和针对PCOS管理的量身定制干预措施.

关键词:

在P-PUP中,P-PUP是P-PUP.在PCOS中,PCOS是PCOS.集群集群是一个集群集群.民族身份民族身份希尔苏特主义 (hirsutism) 是一种过高雄性主义 (hyperandrogenism) 是一种高雄性主义.不被选择的人口.

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