绝经后妇女骨质疏松风险评估工具的比较准确性:系统性审查和网络元分析
Shu-Tong Wang1, Han-Yang Gu1, Zi-Chen Huang2
1Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, PR China.
International journal of nursing studies
|March 4, 2025
概括
简单计算骨质疏松风险估计 (SCORE) 工具在绝经后妇女中显示出更高的灵敏度来检测骨质疏松症,而骨折风险评估工具 (FRAX) 提供了更高的具体性.
科学领域:
- 骨质疏松症的研究研究.
- 诊断准确性的研究研究.
- 妇女健康 妇女健康
背景情况:
- 五种骨质疏松风险评估工具 (FRAX,ORAI,OSIRIS,OST,SCORE) 被美国预防服务工作组认可,用于评估绝经后妇女的骨密度测试需求.
- 这些工具有助于确定是否需要双能X射线吸收计 (DXA) 扫描.
研究的目的:
- 系统地比较五种骨质疏松风险评估工具的敏感性和特异性.
- 评估它们在检测绝经后妇女骨矿物质密度定义的骨质疏松症方面的准确性.
主要方法:
- 在主要数据库 (Cochrane Library,Embase,PubMed,Web of Science) 进行了系统的文献搜索,截至2024年1月29日.
- 包括17项观察性研究,涉及9669名患有骨质疏松症的妇女和34143名没有骨质疏松症的妇女.
- 评估比较准确性是使用聚合赔率比率和SUCRA (积累排名下的表面) 来进行工具排名.
主要成果:
- 与FRAX,ORAI和OST相比,SCORE工具的灵敏度明显更高.
- 弗拉克斯表现出最高的特异性,其次是OSIRIS.
- SCORE (98.2%) 在敏感性方面排名最高,而FRAX (96.7%) 在特异性方面排名最高.
结论:
- 骨质疏松风险评估工具可以根据其性能进行分类:Score,ORAI和OST提供更高的灵敏度.
- FRAX和OSIRIS提供更高的特异性,更准确地识别没有骨质疏松症的个体.
- 工具的选择可能取决于优先考虑的是最大限度地检测骨质疏松症还是准确识别非骨质疏松症患者.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.1K
07:56Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
17.5K
相关概念视频
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
111
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
111
01:20Comparing the Survival Analysis of Two or More Groups
117
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
117
01:31Osteoclasts in Bone Remodeling
2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K