在MESA中慢性炎症相关疾病和心血管疾病
Evan S Manning1, Gautam R Shroff2, David R Jacobs3
1Cardiovascular Division, Department of Medicine, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
慢性炎症相关疾病 (ChrIRD) 很常见,并显著增加死亡风险,特别是与心血管疾病 (CVD) 结合时. 这种双向关系突出显示了炎症.
科学领域:
- 心血管疾病的研究研究.
- 炎症和慢性疾病流行病学.
背景情况:
- 炎症是心血管疾病 (CVD) 发展的关键因素.
- 慢性炎症相关疾病 (ChrIRD) 涵盖各种非心血管,非癌症的疾病.
- 在动脉样硬化多民族研究 (MESA) 中,研究了ChrIRD和心血管疾病之间的相互作用.
研究的目的:
- 定义和描述慢性炎症相关疾病 (ChrIRD).
- 检查ChrIRD与心血管疾病 (CVD) 之间的关联.
- 调查ChrIRD,心血管疾病和死亡率之间的关系.
主要方法:
- 分析了6,791名MESA参与者,在基线时没有明显的心血管疾病.
- 随访时间为17.9年 (中位数).
- 通过住院和死亡记录的ICD代码进行ChrIRD识别;从医疗记录中进行CVD裁决.
- 用于评估风险的时间依赖的比例危险回归.
主要成果:
- ChrIRD的患病率为29%,心血管疾病的患病率为21%,其中11%患有这两种疾病.
- 死亡率仅为ChrIRD为47%,仅为CVD为45%,两者均为67%.
- 心血管疾病增加了ChrIRD风险 (HR:1.48),而ChrIRD增加了心血管疾病风险 (HR:2.23).
- 基线炎症标志物预测了ChrIRD和CVD.
结论:
- ChrIRD在各个器官系统中普遍存在,与死亡率密切相关,特别是与共存的心血管疾病相关.
- 在CVD和ChrIRD之间存在双向关系.
- 基线的炎症标志物可以预测ChrIRD和心血管疾病的发展.
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