工程体系统用于细胞操纵,输送和跟踪
Olga A Sindeeva1, Zhanna V Kozyreva1, Arkady S Abdurashitov2
1Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Moscow 121205, Russia.
Advances in colloid and interface science
|March 4, 2025
概括
工程化合体系统对于生物医学应用至关重要,重点是细胞相互作用和细胞内功能. 本综述详细介绍了用于向药物输送和细胞操纵的合体设计的进展.
科学领域:
- 生物医学科学和纳米技术
- 体和接口科学科学
- 细胞生物学和药物输送
背景情况:
- 人造体系统是生物医学科学不可或缺的组成部分,对量身定制的功能需求越来越大.
- 目前合体设计的挑战包括理解和控制细胞-合体相互作用,细胞吸收和细胞内行为.
研究的目的:
- 审查生物医学应用工程体颗粒的最新进展.
- 专注于环状颗粒与各种人体细胞类型的相互作用.
- 讨论合物在细胞跟踪,药物输送和调节细胞功能的潜力.
主要方法:
- 关于体系统设计和细胞体相互作用的当前文献的综述.
- 对专注于特定细胞类型内体颗粒吸收和行为的研究进行分析.
- 检查涉及细胞膜碎片和外体的策略,以增强体应用.
主要成果:
- 体颗粒正在被设计成与多种细胞类型相互作用并被内部化,包括干细胞,免疫细胞,神经元和血液细胞.
- 用细胞膜碎片和外体构成的状囊泡的工程显示出改善生物相容性和有针对性的输送的前景.
- 研究正在探索细胞跟踪,利用细胞作为药物载体,以及通过合体进行细胞功能调节的外部触发器.
结论:
- 在理解和控制生物医学目的的体细胞相互作用方面取得了重大进展.
- 需要进一步的研究来克服合体设计的局限性和临床翻译的生物障碍.
- 体系统的战略工程为先进的药物输送和细胞疗法提供了有前途的途径.
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