对于急性酸晶体关节炎的研究的核心领域:OMERACT delphi调查以建立共识共识
Yiling Zhang1, Sara K Tedeschi2, Abhishek Abhishek3
1University of Auckland, Auckland, New Zealand.
Seminars in arthritis and rheumatism
|March 4, 2025
概括
这项研究确定了评估急性酸盐 (CPP) 晶体关节炎爆发的关键领域. 核心领域包括关节疼痛,胀,疼痛,功能和患者的整体评估,以更好地评估治疗.
科学领域:
- 类风湿病学 类风湿病学
- 结晶关节病 结晶关节病
- 结果测量 结果测量
背景情况:
- 急性氧化 (CPP) 晶体关节炎是一种炎症性关节炎,需要标准化的结果测量.
- 风湿病学的结果测量 (OMERACT) 计划旨在开发各种类风湿病的核心领域集.
- 确定CPP晶体关节炎爆发的核心域集对于一致和可比的研究至关重要.
研究的目的:
- 确定和建立对评估酸盐 (CPP) 晶体关节炎急性爆发的基本领域的共识.
- 为开发CPP晶体关节炎临床试验和观察性研究的核心领域集提供信息.
主要方法:
- 与患者研究合作伙伴 (PRP) 和其他利益相关者 (临床医生,研究人员) 合作,采用了涉及三轮调查的Delphi方法.
- 共识被定义为PRP和其他参与者群体在一个领域的关键重要性上的至少70%的协议.
- 随后的排名练习进一步优先考虑在核心集合中包含的领域.
主要成果:
- 十四个领域达成共识,认为这些领域至关重要.
- 确定的关键领域包括关节疼痛,疼痛,胀,成像证实的炎症,爆发时间,整体功能,日常任务能力,工作能力,生活质量,患者全球评估,医生全球评估和救援药物使用.
- 关节疼痛,关节疼痛,关节胀,整体功能和完成日常任务的能力排名最高.
结论:
- 关节疼痛,关节胀,关节敏感,发作持续时间,整体功能,完成日常任务的能力,以及患者对疾病活动的整体评估都得到了强烈支持,将其纳入OMERACT核心领域.
- 这些领域代表了急性CPP水晶关节炎爆发患者体验和疾病活动的关键方面.
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