设计基于灵活的阿里法式链接器的分子印记共价有机框架,用于快速和选择性提取和检测微量泽拉伦

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Li-Hong Su¹, Hai-Long Qian², Shu-Ting Xu¹

¹State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China; Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

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|March 4, 2025

概括

一种新的吸附剂,ALCOF-MIP,可以有效地从食品和环境样本中去除zearalenone (ZEN). 这一突破增强了真菌毒素检测,改善了公共卫生和食品安全.

科学领域:

材料科学材料科学材料科学
分析化学分析化学
环境科学环境科学

背景情况:

食品和环境被泽拉伦 (ZEN) 污染对公共健康构成重大风险.
由于复杂的干扰和真实样本中的低残留量,敏感和准确的ZEN检测具有挑战性.

研究的目的:

开发一种新的分子印记共价有机框架 (ALCOF-MIP),用于快速和选择性的提取.
增强水友性和分子构造,以提高ZEN吸附动力学和选择性.

主要方法:

使用灵活的异形链接器合成ALCOF-MIP.
描述ALCOF-MIP对ZEN的吸附特性.
在固体相提取中应用ALCOF-MIP与高性能液态染色学 (HPLC) 相结合.

主要成果:

阿尔科夫-MIP对具有很高的吸附能力 (1250毫克/克),超过了现有的吸附剂.
基于ALCOF-MIP的SPE-HPLC方法证明了广泛的线性范围 (1-500 ng/mL) 和低的检测极限 (0.06 ng/mL).
在真实样本中,高精度 (≤3.2%) 和恢复率 (90.7%-99.1%) 在最小的矩阵干扰下实现.

结论:

阿尔科夫-MIP是一种高度选择性和高效的吸附剂,用于ZEN提取.
开发的方法为敏感的真菌毒素监测和确保食品安全提供了一个有希望的方法.

关键词:

灵活的阿里巴斯链接器有分子印记的共价有机框架.固体相提取方法固体相提取方法泽拉伦没有一个.

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