慢性支气管炎和COPD患者的疾病发病和负担:现实世界的证据研究
Jamuna K Krishnan1, Gerard J Criner2, Bilal H Lashari2
1Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, New York, New York, United States.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|March 4, 2025
概括
慢性支气管炎 (CB) 经常先于慢性阻塞性肺病 (COPD),导致医疗保健成本上升. 管理CB可以预防COPD的进展,并改善患者的治疗结果.
科学领域:
- 肺部病理学 肺部病理学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 慢性支气管炎 (CB) 的定义是持续的咳和唾液的产生.
- CB经常与慢性阻塞性肺病 (COPD) 相关.
研究的目的:
- 识别和比较患者特征,诊断时间和医疗资源利用率 (HCRU) 对于CB,COPD和共存的CB和COPD.
- 在大型电子健康记录数据集中应用CB的经典定义.
主要方法:
- 使用Optum®非识别电子健康记录 (EHR) 数据进行的回顾性队列研究.
- 开发了一种算法,以电子扫描EHR以识别患者.
- 分析包括2007年1月至2020年9月期间超过1.04亿名患者.
主要成果:
- 确定了628,545名仅患有CB的患者,129,084名仅患有COPD的患者,77,749名患有CB和COPD的患者.
- 在被诊断为CB和COPD的患者中,75.9%的患者先前有CB诊断.
- 结合的COPD-CB队列显示了最高的5年HCRU,并发症和药物类暴露.
结论:
- CB经常在COPD诊断之前,强调需要集中注意力.
- 对CB管理的早期干预可以预防COPD的发展并降低发病率.
- 解决CB对于改善COPD风险或COPD患者的治疗结果至关重要.
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