心血管疾病和与代谢功能障碍相关的脂肪性肝病:病理生理学和诊断方面
Søren Møller1,2, Nina Kimer3, Jens Dahlgaard Hove2,4
1Department of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård alle 30, DK-2650 Hvidovre, Denmark.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与代谢综合征有关,并显著增加心血管疾病 (CVD) 风险. 在MASLD患者中,由于心脏事件和死亡率较高,早期心血管疾病监测至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 是代谢综合征的肝脏表现,影响30%的成年人.
- MASLD的主要危险因素包括肥胖,脂质不良,高血压和2型糖尿病 (T2DM).
- 存在双向关系,MASLD在高达75%的T2DM患者中流行.
研究的目的:
- 审查将MASLD与心血管疾病 (CVD) 联系起来的病理生理学.
- 详细说明心血管并发症的类型,相关发病率和MASLD患者的存活率.
- 为患有MASLD的个体提供系统CVD评估的建议.
主要方法:
- 文献综述侧重于病理生理学,临床结果和诊断策略.
- 对MASLD中心脏病发病率和影响的现有数据的分析.
- 综合有关MASLD心血管风险分层的现有证据.
主要成果:
- MASLD独立地与各种心血管疾病的风险增加有关,包括心律不整,动脉样性心脏病和心力衰竭.
- 患有MASLD的患者表现出较高的重大心脏不良事件发生率和心血管疾病相关死亡率增加.
- 病理生理学涉及共享的代谢途径和炎症过程,有助于肝脏和心血管损伤.
结论:
- MASLD显著提高了心血管并发症和死亡率的风险.
- 对所有MASLD患者进行系统的心血管监测是有必要的.
- 了解病理生理学是制定MASLD中心血管疾病的有针对性的预防和治疗策略的关键.
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