丸激素治疗对变性男性和非二进制人的阴道微生物群的影响:一项前性研究
Olivia T Van Gerwen1, Kristal J Aaron1, Emma Sophia Kay2
1Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.
The Journal of infectious diseases
|March 4, 2025
概括
在跨性别男性 (TGM) 和非二进制个体中,激素治疗可能导致阴道失调和发生细菌性阴道炎 (iBV). 需要进一步的研究来了解这些微生物群随着时间的推移而发生的变化.
科学领域:
- 生殖健康 生殖健康
- 微生物组研究 微生物组研究
- 内分泌学 在内分泌学.
背景情况:
- 阴道失生症和发生的细菌性阴道炎 (iBV) 与生殖器症状和艾滋病毒/性传播感染风险增加有关.
- 了解对跨性别男性 (TGM) 和非二进制个体的阴道微生物群的影响至关重要.
研究的目的:
- 为了调查阴道微生物组合的变化随着时间的推移在TGM开始丸激素治疗.
- 在这个人群中评估阴道失生症和IBV的发展.
主要方法:
- 注册参与者 (≥18岁) 在出生时被分配为女性,确定为TGM或非二进制,开始注射性丸.
- 每天收集的阴道样本在7天前和90天后开始测试.
- 使用阴道格拉姆染色和16S rRNA基因测序;定义了失生症 (努根特得分≥4) 和IBV (努根特得分≥7).
主要成果:
- 89%的参与者出现了阴道失调,而56%的参与者在开始使用丸激素后出现了IBV.
- iBV发作主要发生在启动后的20-40天之间.
- 社区状态类型 (CST) I与iBV无关,而CST IV-B与iBV相关;性活动和月经也影响了iBV.
结论:
- 在TGM和非二进制个体中,激素治疗通常会导致阴道失生症,包括IBV.
- 需要进行更大规模的研究才能充分了解丸激素对阴道微生物群的影响.
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