功能和认知障碍:系统审查和元分析
Xiaohua Pei1, Nazia Begum Bakerally1, Zhan Wang2
1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Renal failure
|March 4, 2025
概括
认知障碍 (CI) 的患病率随着功能下降而增加. 慢性病 (CKD) 患者面临多种风险因素,包括糖尿病和心血管疾病,导致认知能力下降.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 缺乏对功能与认知障碍 (CI) 患病率以及相关风险因素之间的关联的全球评估.
- 之前的研究已经表明了潜在的联系,但需要进行全面的全球评估.
研究的目的:
- 对功能与认知障碍 (CI) 患病率之间的关系进行全球评估.
- 识别和分析与不同程度的功能个人认知障碍相关的风险因素.
主要方法:
- 在2024年11月之前发表的研究的系统审查和元分析,从PubMed和Web of Science获取.
- 通过使用R软件和Review Manager,分析不同估计的淋巴细胞过率 (eGFR) 水平和相关风险因素的认知障碍患病率.
- 随机模型效应用于异质性超过50% (I2).
主要成果:
- 这项分析包括了17项涉及32,141名参与者的研究.
- 认知障碍患病率随着功能下降显著增加:10% (eGFR ≥60),47.3% (eGFR 30-60),和60.6% (eGFR <30),总患病率为16.7%.
- 确定的主要危险因素包括2型糖尿病 (T2DM),心血管疾病,脑血管疾病,低学历,晚年和偏甲状腺激素 (PTH) 水平升高.
结论:
- 较差的功能与较高的认知障碍患病率直接相关.
- 患有慢性病 (CKD) 的个人表现出多种风险因素,这些因素有助于认知障碍的发展.
相关概念视频
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