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研究聚合物对治疗性深度浸泡溶剂的形成和稳定性的影响:基于热分析的方法来优化聚合物选择

Magdy M Abdelquader¹, Shu Li², Gavin P Andrews²

¹Pharmaceutical Engineering Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK; Pharmaceutical Technology Department, Faculty of Pharmacy, Tanta University, Tanat, Egypt.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

|March 4, 2025

概括

治疗性深层欧性溶剂 (THEDES) 可以增强药物特性,但聚合物封装可以破坏它们的稳定性. 这项研究量化了聚合物对THEDES形成和稳定性的影响,为药物输送系统设计提供了指导.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
聚合物化学聚合物化学

背景情况:

治疗性深溶性溶剂 (THEDES) 提高了药物的溶解性和透性.
聚合物中的封装可能会破坏THEDES的键和稳定性.
聚合物对THEDES在加工过程中的形成和稳定性的影响尚不清楚.

研究的目的:

为了研究模型聚合物 (PEVA,PEO,EuRLPO) 对利多卡因的形成和稳定性的影响:flurbiprofen (1:1) THEDES.
评估聚合物药物相互作用及其对THEDES的影响.
为选择聚合物提供建议,以保持药物输送系统中的THEDES稳定性.

主要方法:

利用聚合物和药物的热处理.
采用调制温度差扫描热量计 (MTDSC) 在现场定量THEDES.
评估了聚合物药物相互作用和长期储存稳定性.

主要成果:

由于粘度增加,聚合物类型显著影响了THEDES形成速度,PEVA < EuRLPO < PEO.
与PEVA不同,PEO和EuRLPO与THEDES组件相互作用,破坏了预成型THEDES的稳定性.
使用PEVA和EuRLPO在长时间加热后可以实现完整的THEDES形成,但使用PEO却无法实现.

结论:

聚合物-药物相互作用对于THEDES的稳定性至关重要,在某些情况下超越粘度效应.
PEVA显示的相互作用最小,这表明它适合THEDES封装.
这项研究为合理的聚合物选择提供了关键的见解,以确保THEDES在制药配方中的稳定性.

关键词:

弗鲁尔比普罗芬 (Flurbiprofen) 是一种可怕的药物.通过气结合,形成了气结合.在现场定量化量化.利多卡因 (Lidocaine) 是一种药物.调节温度的DSC可以调节温度.聚合物聚合物聚合物这就是TEDES.热分析是一种热分析.

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