健行式血压生物标志物可以预测老年人未来的跌倒吗?
Rachel Madden1,2, Ciara Rice1,3, Amanda Lavan1,3
1Falls and Syncope Unit, Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.
Age and ageing
|March 4, 2025
概括
门诊血压监测 (ABPM) 生物标志物,如低血压发作和早晨激增,与老年人的跌倒有关. 这些ABPM发现表明老年患者未来跌倒的风险可以修改.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 神经学 神经学
背景情况:
- 门诊血压监测 (ABPM) 生物标志物可以预测心血管和脑血管事件.
- 关于ABPM生物标志物与老年人跌之间的关联,研究有限.
- 跌倒是对老年人发病率和死亡率的一个重大问题.
研究的目的:
- 调查ABPM生物标志物与随后跌倒的发生之间的关系.
- 确定特定的ABPM参数,这些参数可以作为老年人中跌倒的预测指标,这些老年人有跌倒史.
主要方法:
- 一组118名70岁及以上的近期跌倒的患者接受了24小时的ABPM.
- 分析的ABPM生物标志物包括静脉血压 (sBP) 变化,最小的sBP,低血压发作,sBP浸泡模式和sBP早晨激增.
- 用物流回归模型来评估ABPM生物标志物与事故跌倒之间在至少1个月的随访期间之间的关联.
主要成果:
- 四分之一的参与者在平均7个月的随访时间内再次下降.
- 低压情节与进一步跌倒的风险增加有显著的关联 (OR 4.52).
- 增加的sBP早晨激增与更高的跌倒发病率有关 (或1.06每mmHg增加),而较低的最低sBP也预测跌倒 (或0.97每mmHg增加).
结论:
- 包括低血压发作和sBP早晨激增在内的ABPM生物标志物是老年人未来跌倒的重要预测因素.
- 这些发现表明,ABPM生物标志物代表了潜在的可修改的跌倒风险因素.
- 建议将ABPM整合到老年患者的综合性跌倒评估中.
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