耳鼻黄金葡萄球菌与长期老年护理居民的死亡率较高有关
Sophie J Miller1,2, Frank Zhang3, Steven Taylor1,2
1Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
在老年护理人员中,口腔黄金葡萄球菌的携带与因任何原因死亡的风险更高有关. 这一发现表明,金杆菌可以作为老年人整体健康的标志物.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 生物衰老和环境因素改变了老年人的口腔 (OP) 微生物群.
- 这些微生物组的变化可能会增加对病原生物殖民的易感性,影响健康结果.
研究的目的:
- 检查OP微生物组组成和长期老年护理机构居民所有原因死亡率之间的关联.
主要方法:
- 从190名老年护理居民中采集了口腔喉抽样.
- 射门甲基因组学分析了微生物群组成,qPCR证实了金黄色葡萄球菌的携带和对甲基西林的耐药性.
- 在12个月的随访期间,对健康结果进行了跟踪.
主要成果:
- 黄金葡萄球菌在6.8%的居民中被检测到.
- 携带S. aureus显著增加死亡风险 (调整HR:9.7),独立于抗生素耐药性.
- 黄金菌携带与死亡率的关联比伴随性疾病数量更强.
结论:
- 口腔黄金菌携带是长期老年护理机构所有原因死亡率的预测因素.
- 黄金菌携带可能表明一般健康状况和先前的医疗保健暴露.
- 检测OP S. aureus可以为老年人的护理策略提供信息.
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