德诺苏马布在治疗原发性甲状腺功能障碍症高热血症的有效性和安全性:一项回顾性研究
An Song1, Yingyu Chen1, Rong Chen1
1Key laboratory of Endocrinology, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
The Journal of clinical endocrinology and metabolism
|March 4, 2025
概括
德诺苏马布有效地降低了原发性甲状腺功能障碍症 (PHPT) 患有高血症的患者的,其疗效与索莱德龙酸相当. 这种治疗提供了持续响应的持续时间,没有严重的不良事件.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 德诺苏马布已批准用于恶性瘤的高血症.
- 有限的数据存在于denosumab对原发性甲状腺功能障碍症 (PHPT) 相关的高血症的疗效.
研究的目的:
- 为了比较denosumab与zoledronic acid在治疗PHPT相关的高血症中的疗效和安全性.
- 评估denosumab在降低PHPT患者血清水平方面的有效性.
主要方法:
- 对58名PHPT患者进行了回顾性研究,这些患者患有中度/重度高血症 (经校正的血清 [CSC] ≥3.0 mmol/L).
- 29名患者接受了登苏马布 (60或120毫克) 和29名患者接受了佐莱德龙酸 (4毫克) 治疗.
- 主要结果:CSC (ΔCa) 的变化;次要结果:响应比例,响应时间,响应持续时间和安全.
主要成果:
- 德诺苏马布和龙酸都显著降低了CSC水平 (p<0.01).
- 德诺苏马布实现了82.8%的响应率 (CSC<3.0 mmol/L) 和72.4%的完整响应 (CR).
- 代诺苏马布的反应持续时间较长 (19.0 vs. 13.0 天,p=0.02),但CR的时间较慢 (7.0 vs. 3.0 天). 低血症发生在6.9%的denosumab患者中.
结论:
- 单次60毫克的登苏马布剂量有效降低PHPT患者中度/重度高血症的血清.
- 德诺苏马布的疗效与索尔德龙酸相当,反应持续时间较长.
- 德诺苏马布在与PHPT相关的高血症中似乎是安全的,没有报告严重的不良事件.
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