默认模式是网络,无组织和耐治疗精神分裂症
Huan Huang1,2, Xuan Qin1, Rui Xu1
1Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Schizophrenia bulletin
|March 4, 2025
概括
耐治疗精神分裂症 (TRS) 显示出改变的默认模式网络 (DMN) 功能,具有更高的空间突出性和更低的时间变化. DMN 功能障碍可能代表精神分裂症的一种谱,随着治疗耐药性而恶化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 混乱的思维是精神分裂症的一个关键特征,特别是在治疗耐药的病例中.
- 默认模式网络 (DMN) 干扰是精神分裂症的一个已知的特征,影响自我参考思维.
- 对于DMN中断在混乱和治疗抵抗中的具体作用尚不清楚.
研究的目的:
- 调查DMN在治疗耐药精神分裂症 (TRS) 的时空特征.
- 为了确定DMN的变化是否与混乱的思维和治疗阻力相关.
- 探索DMN作为精神分裂症谱系障碍中的潜在连续性.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于48名TRS患者,76名非TRS患者和64名健康对照.
- 多变量组独立组分分析确定了DMN,评估了它的空间负载和时间.
- 伏塞尔级分析检查了DMN的同质性和,回归研究了DMN-失序关系.
主要成果:
- 与健康对照组 (HC) 相比,耐治疗的精神分裂症 (TRS) 呈现出更高的DMN空间负载和更低的时间.
- 非TRS患者显示了中间的DMN变化,表明连续性.
- 较高的DMN负载系数显著与失调的严重程度增加有关.
结论:
- 耐治疗精神分裂症 (TRS) 可能是DMN时空功能障碍最严重的表现.
- 越来越多的DMN空间贡献与混乱有着特别的联系.
- 德国脑神经网络的空间贡献和时间稳定性都具有精神分裂症的特征,并且随着治疗耐药性而加剧.
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