癌症患者血管运动症状的管理
Ling Zhu1,2, Tammy T Hshieh3, Tara K Iyer4
1Department of Endocrinology, Singapore General Hospital, Singapore 169856.
The oncologist
|March 4, 2025
概括
癌症治疗可以引起热和其他血管运动症状 (VMS),由于性激素的低水平. 本综述探讨了VMS治疗方法,包括新的选择,如fezolinetant,癌症患者.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 癌症治疗通常会降低性激素,导致诸如热之类的血管运动症状 (VMS).
- 静脉神经系统会对癌症患者的生活质量,治疗坚持和耐受性产生负面影响.
- 激素治疗对于VMS是有效的,但在激素敏感癌症中通常是禁忌的.
研究的目的:
- 审查癌症患者的VMS管理.
- 评估该群体中VMS的当前和新型治疗选择.
- 根据癌症类型和患者人口统计数据,讨论VMS管理的特殊考虑.
主要方法:
- 对癌症患者的VMS现有文献的叙述性综述.
- 对激素治疗和非激素药物的证据评估.
- 探索新的治疗点,包括下丘脑热调节通路.
主要成果:
- 激素治疗是一种标准的VMS治疗方法,但在激素敏感癌症中具有禁忌.
- 非激素药物提供了替代品,但可能具有有限的疗效和耐受性.
- 新型药物,如针对下垂体通路的fezolinetant,显示出有希望的结果.
结论:
- 有效管理VMS对于改善癌症患者的生活质量和治疗结果至关重要.
- 有一系列的治疗选择,仔细考虑癌症类型和患者因素.
- 新兴疗法为在具有挑战性的患者群体中管理VMS提供了新的途径.
相关概念视频
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
Tumor Immunotherapy
461
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
461
Asthma-IV: Nursing Management
2.9K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
First, in...
2.9K
COPD: Management Using Bronchodilators and Corticosteroids
170
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
170
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
199
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
199


