心理语言测试预测现实世界的药物名称混错误率:一个横截面实验研究
Bruce L Lambert1, Scott Ryan Schroeder2, William L Galanter3
1Communication Studies, Northwestern University, Chicago, Illinois, USA bruce.lambert@northwestern.edu.
BMJ quality & safety
|March 4, 2025
概括
心理语言测试准确地预测现实世界的药物名称混错误. 这些基于实验室对单个药物名称的评估可以帮助监管机构在到达患者之前识别可能令人困惑的药物,从而提高药物安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 人类因素工程 人类因素工程
- 医疗信息学 医疗信息学
背景情况:
- 错误的药物药物错误是一个重要的患者安全问题.
- 目前对于药品名称混性的监管选方法缺乏经验验证.
- 以前的研究将药物名称对的心理语言测试与药房错误联系起来,但监管机构会评估个别名称.
研究的目的:
- 为了确定单个药物名称在心理语言测试中的表现是否与其现实世界的错误率相关.
- 为了验证心理语言测试的使用,以评估个体药物名称的混性.
主要方法:
- 在模拟感官或记忆障碍的条件下,使用记忆和感知任务测试了77种药物名称.
- 药剂师和药房技术人员参与了测试,记录了感知到的药物名称.
- 实验室错误率与来自全国连锁药店患者安全组织的现实错误数据进行了比较.
主要成果:
- 在实验室平均错误率和经日志调整的现实错误率之间发现了显著的正相关性 (r=0.50,p<0.0001).
- 线性和混合效应物流回归证实,实验室测量的错误率显著预测了现实世界的错误率,反之亦然.
结论:
- 基于实验室的心理语言测试被证明与现实世界的药物名称混错误有关.
- 这些发现扩展了先前的工作,通过显示实验室测试与单个药物名称的整体错误率相关,而不仅仅是对.
- 心理语言测试提供了一种经过验证的方法,用于在监管审查期间评估拟议药物名称的潜在混性.
更多相关视频
07:26The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory
Published on: January 31, 2017
37.8K
12:49Transcranial Direct Current Stimulation tDCS of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition
Published on: July 13, 2019
16.7K
相关概念视频
Drug Nomenclature
1.6K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
1.6K
Blind Procedures
10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K
Combined Effects of Drugs: Antagonism
8.2K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
8.2K
Tip-of-the-Tongue Phenomenon
93
The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...
93
Language and Cognition
313
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
313
