自我报告的分裂型维度与青春期白质完整性发展之间的纵向关联
Mélodie Derome1,2, Suje Amir3,4, Elodie Sprüngli-Toffel5,6
1Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
Schizophrenia bulletin
|March 4, 2025
概括
精神分裂,一种人格特征,与青春期和年轻成年期大脑中的白质变化有关,这表明它可能预测精神病风险. 这些发现突显了精神病谱系障碍风险较高的人早期神经发育变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 在精神病谱系障碍中观察到白质微观结构的改变.
- 在临床前阶段这些变化的发育轨迹尚不清楚.
- 精神分裂型研究提供了一个框架,用于调查精神病谱系障碍的先发性风险.
研究的目的:
- 在典型发育的个体中研究分裂型维度和白质微观结构发育之间的关系.
- 为了检查白质完整性与年龄相关的变化是如何与纵向分裂型的轨迹相关的.
- 探索精神分裂性作为潜在的神经发育标志物用于精神病风险.
主要方法:
- 对102个典型发育的个体 (在基线时12-20岁) 的长度研究.
- 评估了精神分裂型,并进行了脑成像 (每位参与者进行1-4次扫描).
- 使用扩散张力成像 (DTI) 和混合效应模型分析白质区域.
主要成果:
- 阳性精神分裂症随着前丘脑辐射 (atr-FA) 的分数异位变异 (FA) 的增加而减少,特别是在年轻人中.
- 无组织的精神分裂表现出与atr-FA的年龄相关联,在青少年中增加,在老年参与者中减少.
- 在带状回形中发现了积极的精神分裂和FA,在上长纵中发现了混乱的精神分裂和FA.
结论:
- 结果支持精神分裂症作为精神病的基于人格的风险因素的假设.
- 观察到的前额 - thalamo - 带电路中的白质异常与精神分裂症和精神病转换器的发现一致.
- 精神分裂症可能代表精神病责任的早期神经发育标志物.
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